Mouse Anti-RAET1E Recombinant Antibody (50/3) (CBMAB-R1163-CN)

Name: Mouse Anti-RAET1E Recombinant Antibody (50/3)
SKU: CBMAB-R1163-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

50/3

Application

ELISA, FC, IF, IP, Neut, WB

Immunogen

Recombinant His-tagged protein to human extra-cellular domain of RAET1E, grown in E.coli

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

retinoic acid early transcript 1E

Introduction

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Entrez Gene ID

135250

UniProt ID

Q8TD07

Alternative Names

Retinoic Acid Early Transcript 1E; Lymphocyte Effector Toxicity Activation Ligand; RAE-1-Like Transcript 4; UL16-Binding Protein 4; NKG2D Ligand 4; NKG2DL4; N2DL-4;

Function

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Biological Process

Biological Process natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Membrane
Isoform 4
Secreted

Topology

Extracellular: 31-225
Helical: 226-248
Cytoplasmic: 249-263

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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