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Mouse Anti-RAET1E Recombinant Antibody (709116) (CBMAB-C1033-CN)

This product is a Mouse antibody that recognizes RAET1E. The antibody 709116 can be used for immunoassay techniques such as: FC.
See all RAET1E antibodies
Published Data
Fig.1 NKG2D and DNAM-1 play a role in chemotherapy-induced sensitivity to DNTs.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
709116
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant human ULBP-4/RAET1E, Gly30-Asp225, Accession # Q8TD07
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Saline solution, BSA
Preservative
Sodium azide

Target

Full Name
retinoic acid early transcript 1E
Introduction
This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]
Entrez Gene ID
135250
UniProt ID
Q8TD07
Alternative Names
Retinoic Acid Early Transcript 1E; Lymphocyte Effector Toxicity Activation Ligand; RAE-1-Like Transcript 4; UL16-Binding Protein 4; NKG2D Ligand 4; NKG2DL4; N2DL-4;
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Biological Process
Biological Process natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Isoform 4
Secreted
Topology
Extracellular: 31-225
Helical: 226-248
Cytoplasmic: 249-263
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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