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RBM3

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]

Full Name

RNA binding motif (RNP1, RRM) protein 3

Function

Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).

Biological Process

Biological Process positive regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationISS:UniProtKB
Biological Process regulation of translationISS:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus
Cytoplasm
Cell projection, dendrite
Localizes in mRNA granules in dentrites.

PTM

Arg-105 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated.

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Anti-RBM3 antibodies

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Mouse Anti-RBM3 Recombinant Antibody (CL0296) (CBMAB-R1733-CN)

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Target: RBM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CL0296

Application*: WB, IH, IF, P

Mouse Anti-RBM3 Recombinant Antibody (CBCNR-301) (CBMAB-R1731-CN)

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Target: RBM3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBCNR-301

Application*: WB, P

Mouse Anti-RBM3 Recombinant Antibody (CBCNR-300) (CBMAB-R1730-CN)

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Target: RBM3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBCNR-300

Application*: E, WB, P

Mouse Anti-RBM3 Recombinant Antibody (4D6) (CBMAB-R1729-CN)

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Target: RBM3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4D6

Application*: E, IH, WB

Rabbit Anti-RBM3 Recombinant Antibody (CBCNR-299) (CBMAB-R0157-CN)

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Target: RBM3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBCNR-299

Application*: WB, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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