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Mouse Anti-RBM3 Recombinant Antibody (4D6) (CBMAB-R1729-CN)

This product is a Mouse antibody that recognizes RBM3. The antibody 4D6 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all RBM3 antibodies
Published Data
Fig.1 Immunohistochemical staining of RBM3 in astrocytomas and normal brain tissues.
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Fig.2 Western blotting analysis of RBM3 expression in astrocytomas and normal brain tissues.
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Fig.3 Immunohistochemical images of RBM3 expression in astrocytoma.
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Fig.4 Expression of RBM3, HuR, and CUGBP-2 protein in YAMC-Vec and YAMCErbB4 cells was determined by Western blot analysis.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4D6
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Recombinant corresponding to aa. 1-81 from human RBM3 with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL

Target

Full Name
RNA binding motif (RNP1, RRM) protein 3
Introduction
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Entrez Gene ID
5935
UniProt ID
P98179
Alternative Names
RNA Binding Motif Protein 3; RNPL; RNA Binding Motif (RNP1, RRM) Protein 3; RNA-Binding Motif Protein 3; RNA-Binding Protein 3; IS1-RNPL;
Function
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).
Biological Process
Biological Process positive regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationISS:UniProtKB
Biological Process regulation of translationISS:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Cell projection, dendrite
Localizes in mRNA granules in dentrites.
PTM
Arg-105 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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