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Rabbit Anti-RBM3 Recombinant Antibody (CBCNR-299) (CBMAB-R0157-CN)

This product is a Rabbit antibody that recognizes RBM3. The antibody CBCNR-299 can be used for immunoassay techniques such as: WB, IF.
See all RBM3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBCNR-299
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
RNA binding motif (RNP1, RRM) protein 3
Introduction
This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Multiple alternatively spliced transcript variants that are predicted to encode different isoforms have been characterized although some of these variants fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human5935
Mouse19652
Rat114488
UniProt ID
HumanP98179
MouseO89086
RatQ925G0
Alternative Names
RNA Binding Motif Protein 3; RNPL; RNA Binding Motif (RNP1, RRM) Protein 3; RNA-Binding Motif Protein 3; RNA-Binding Protein 3; IS1-RNPL;
Function
Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation (By similarity).
Biological Process
Biological Process positive regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of translationISS:UniProtKB
Biological Process regulation of translationISS:UniProtKB
Biological Process RNA processingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Cytoplasm
Cell projection, dendrite
Localizes in mRNA granules in dentrites.
PTM
Arg-105 is dimethylated, probably to asymmetric dimethylarginine.
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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