Reg3B

Lectin-related secretory protein; may be involved in stress response to control bacterial proliferation during acute pancreatitis [RGD, Feb 2006]

Full Name

Regenerating family member 3 beta

Function

Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell deathISO:MGI
Biological Process negative regulation of hydrogen peroxide-induced neuron deathISO:MGI
Biological Process negative regulation of neuron apoptotic processISO:MGI
Biological Process positive regulation of cell population proliferationISO:MGI
Biological Process positive regulation of protein phosphorylationISO:MGI
Biological Process response to bacteriumManual Assertion Based On ExperimentIEP:MGI
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Found in the apical region of pancreatic acinar cells.

Involvement in disease

Overexpressed during the acute phase of pancreatitis.

PTM

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.