Reg3B

Lectin-related secretory protein; may be involved in stress response to control bacterial proliferation during acute pancreatitis [RGD, Feb 2006]

Regenerating family member 3 beta

Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell deathISO:MGI
Biological Process negative regulation of hydrogen peroxide-induced neuron deathISO:MGI
Biological Process negative regulation of neuron apoptotic processISO:MGI
Biological Process positive regulation of cell population proliferationISO:MGI
Biological Process positive regulation of protein phosphorylationISO:MGI
Biological Process response to bacteriumManual Assertion Based On ExperimentIEP:MGI
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central

Secreted
Found in the apical region of pancreatic acinar cells.

Overexpressed during the acute phase of pancreatitis.

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.