Rat Anti-REG3B Recombinant Antibody (CBFYH-3654) (CBMAB-H4215-FY)

Name: Rat Anti-REG3B Recombinant Antibody (CBFYH-3654)
SKU: CBMAB-H4215-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBFYH-3654

Application

Specificity

Mouse

Antibody Isotype

IgG2

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Regenerating family member 3 beta

Introduction

Reg3b plays a protective role against intestinal translocation of the Gram-negative bacterium S. enteritidis in mice, but not against the Gram-positive bacterium L.

Entrez Gene ID

18489

UniProt ID

P35230

Alternative Names

HIP; Pap; PAP1; REG-III

Function

Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.

Biological Process

Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell deathISO:MGI
Biological Process negative regulation of hydrogen peroxide-induced neuron deathISO:MGI
Biological Process negative regulation of neuron apoptotic processISO:MGI
Biological Process positive regulation of cell population proliferationISO:MGI
Biological Process positive regulation of protein phosphorylationISO:MGI
Biological Process response to bacteriumManual Assertion Based On ExperimentIEP:MGI
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted
Found in the apical region of pancreatic acinar cells.

Involvement in disease

Overexpressed during the acute phase of pancreatitis.

PTM

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-Reg3B Recombinant Antibody (293523) (CAT#: CBMAB-R2071-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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