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Mouse Anti-Reg3B Recombinant Antibody (293523) (CBMAB-R2071-CN)

This product is a Mouse antibody that recognizes Reg3B. The antibody 293523 can be used for immunoassay techniques such as: WB, IHC.
See all Reg3B antibodies

Summary

Host Animal
Mouse
Specificity
Rat
Clone
293523
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
E. coli-derived recombinant rat Reg3B, Glu27-Gly175, Accession # P25031
Specificity
Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
Regenerating family member 3 beta
Introduction
Lectin-related secretory protein; may be involved in stress response to control bacterial proliferation during acute pancreatitis [RGD, Feb 2006]
Entrez Gene ID
24618
UniProt ID
P25031
Alternative Names
Pap; Pap1
Function
Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues.
Biological Process
Biological Process acute-phase responseIEA:UniProtKB-KW
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cell wall disruption in another organismManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell deathISO:MGI
Biological Process negative regulation of hydrogen peroxide-induced neuron deathISO:MGI
Biological Process negative regulation of neuron apoptotic processISO:MGI
Biological Process positive regulation of cell population proliferationISO:MGI
Biological Process positive regulation of protein phosphorylationISO:MGI
Biological Process response to bacteriumManual Assertion Based On ExperimentIEP:MGI
Biological Process response to peptide hormoneManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted
Found in the apical region of pancreatic acinar cells.
Involvement in disease
Overexpressed during the acute phase of pancreatitis.
PTM
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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