RNASE1

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq]
Full Name
ribonuclease, RNase A family, 1 (pancreatic)
Function
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA.
Biological Process
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA phosphodiester bond hydrolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
PTM
N-linked glycans are of complex type.
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Anti-RNASE1 antibodies

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Mouse Anti-RNASE1 Recombinant Antibody (02) (CBMAB-R2847-CN)

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Target: RNASE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E
Datasheet SDS

Mouse Anti-RNASE1 Recombinant Antibody (CBCNR-557) (CBMAB-R2851-CN)

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Target: RNASE1
Host: Mouse
Specificity: Human
Clone: CBCNR-557
Application*: WB, ICC, P, C, E
Datasheet SDS

Mouse Anti-RNASE1 Recombinant Antibody (CBCNR-556) (CBMAB-R2850-CN)

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Target: RNASE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBCNR-556
Application*: E
Datasheet SDS

Mouse Anti-RNASE1 Recombinant Antibody (1E5) (CBMAB-R2849-CN)

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Target: RNASE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E5
Application*: E
Datasheet SDS

Rabbit Anti-RNASE1 Recombinant Antibody (058) (CBMAB-R2848-CN)

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Target: RNASE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 058
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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