RNF144B

RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF144A.
Full Name
Ring Finger Protein 144B
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion membrane
Cytoplasm
Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Topology
Helical: 258-278
PTM
Auto-ubiquitinated.
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Anti-RNF144B antibodies

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Mouse Anti-RNF144B Recombinant Antibody (CBYY-I1412) (CBMAB-I2582-YY)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1412
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (CBYY-I1152) (CBMAB-I2320-YY)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1152
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (CBCNR-581) (CBMAB-R2944-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-581
Application*: E, WB, P, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (9H10) (CBMAB-R2943-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H10
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (7H2) (CBMAB-R2942-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H2
Application*: F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (6B5) (CBMAB-R2941-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B5
Application*: F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (6B11) (CBMAB-R2940-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B11
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (4F1) (CBMAB-R2939-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F1
Application*: E, IF, IH, WB
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (3D7) (CBMAB-R2938-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D7
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (3C2) (CBMAB-R2937-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C2
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (1G5) (CBMAB-R2936-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G5
Application*: F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (1E1) (CBMAB-R2935-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E1
Application*: F
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (12B6) (CBMAB-R2934-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12B6
Application*: F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (11G1) (CBMAB-R2933-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11G1
Application*: F, IF
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (11F4) (CBMAB-R2932-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11F4
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-RNF144B Recombinant Antibody (10A12) (CBMAB-R2931-CN)

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Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A12
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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