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RNF144B

RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF144A.
Full Name
Ring Finger Protein 144B
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion membrane
Cytoplasm
Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Topology
Helical: 258-278
PTM
Auto-ubiquitinated.

Anti-RNF144B antibodies

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Mouse Anti-RNF144B Recombinant Antibody (CBYY-I1412) (CBMAB-I2582-YY)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1412
Application*: WB, F, IH, IF, P

Mouse Anti-RNF144B Recombinant Antibody (CBYY-I1152) (CBMAB-I2320-YY)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1152
Application*: WB, F, IF

Mouse Anti-RNF144B Recombinant Antibody (CBCNR-581) (CBMAB-R2944-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBCNR-581
Application*: E, WB, P, IF

Mouse Anti-RNF144B Recombinant Antibody (9H10) (CBMAB-R2943-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H10
Application*: F, IF, IH, WB

Mouse Anti-RNF144B Recombinant Antibody (7H2) (CBMAB-R2942-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H2
Application*: F, IF

Mouse Anti-RNF144B Recombinant Antibody (6B5) (CBMAB-R2941-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B5
Application*: F, IF

Mouse Anti-RNF144B Recombinant Antibody (6B11) (CBMAB-R2940-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B11
Application*: WB, IF, F

Mouse Anti-RNF144B Recombinant Antibody (4F1) (CBMAB-R2939-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F1
Application*: E, IF, IH, WB

Mouse Anti-RNF144B Recombinant Antibody (3D7) (CBMAB-R2938-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D7
Application*: F, IF, WB

Mouse Anti-RNF144B Recombinant Antibody (3C2) (CBMAB-R2937-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C2
Application*: F, IF, WB

Mouse Anti-RNF144B Recombinant Antibody (1G5) (CBMAB-R2936-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G5
Application*: F, IF

Mouse Anti-RNF144B Recombinant Antibody (1E1) (CBMAB-R2935-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E1
Application*: F

Mouse Anti-RNF144B Recombinant Antibody (12B6) (CBMAB-R2934-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12B6
Application*: F, IF

Mouse Anti-RNF144B Recombinant Antibody (11G1) (CBMAB-R2933-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11G1
Application*: F, IF

Mouse Anti-RNF144B Recombinant Antibody (11F4) (CBMAB-R2932-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11F4
Application*: F, IF, WB

Mouse Anti-RNF144B Recombinant Antibody (10A12) (CBMAB-R2931-CN)

Datasheet SDS
Target: RNF144B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10A12
Application*: WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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