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Mouse Anti-RNF144B Recombinant Antibody (3C2) (CBMAB-R2937-CN)

This product is a Mouse antibody that recognizes RNF144B. The antibody 3C2 can be used for immunoassay techniques such as: FC, IF, WB.
See all RNF144B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3C2
Antibody Isotype
IgG1
Application
FC, IF, WB

Basic Information

Immunogen
A human recombinant protein fragment corresponding to aa. 1-256 of human RNF144B (NP_877434) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5-1 mg/mL

Target

Full Name
Ring Finger Protein 144B
Introduction
RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF144A.
Entrez Gene ID
UniProt ID
Alternative Names
Ring Finger Protein 144B; P53-Inducible RING Finger Protein; IBR Domain-Containing Protein 2; RING Finger Protein 144B; IBR Domain Containing 2; P53RFP; IBRDC2;
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Mitochondrion membrane
Cytoplasm
Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.
Topology
Helical: 258-278
PTM
Auto-ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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