Mouse Anti-RNF144B Recombinant Antibody (12B6) (CBMAB-R2934-CN)

Name: Mouse Anti-RNF144B Recombinant Antibody (12B6)
SKU: CBMAB-R2934-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

12B6

Application

FC, IF

Immunogen

A human recombinant protein fragment corresponding to aa. 1-256 of human RNF144B (NP_877434) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5-1 mg/mL

More Infomation

Target

Full Name

Ring Finger Protein 144B

Introduction

RNF144B (Ring Finger Protein 144B) is a Protein Coding gene. Among its related pathways are Innate Immune System and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF144A.

Entrez Gene ID

255488

UniProt ID

Q7Z419

Alternative Names

Ring Finger Protein 144B; P53-Inducible RING Finger Protein; IBR Domain-Containing Protein 2; RING Finger Protein 144B; IBR Domain Containing 2; P53RFP; IBRDC2;

Function

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion membrane
Cytoplasm
Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation.

Topology

Helical: 258-278

PTM

Auto-ubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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