RRAGC

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Full Name

Ras Related GTP Binding C

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279).
Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279).
This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279).

Biological Process

Biological Process apoptotic process1 PublicationNAS:UniProtKB
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusISS:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationISS:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to amino acidManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA splicing1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Lysosome
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942).

Involvement in disease

RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.