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Rabbit Anti-RRAGC Recombinant Antibody (D8H5) (CBMAB-R3641-CN)

This product is a Rabbit antibody that recognizes RRAGC. The antibody D8H5 can be used for immunoassay techniques such as: FC, ICC, IF, IP, WB.
See all RRAGC antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D8H5
Antibody Isotype
IgG
Application
FC, ICC, IF, IP, WB

Basic Information

Immunogen
synthetic peptide corresponding to residues in the amino terminus of human RagC
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.01M HEPES, 0.15M NaCl, 0.1mg/mL BSA, 50% Glycerol, pH 7.5
Preservative
No preservatives

Target

Full Name
Ras Related GTP Binding C
Introduction
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Entrez Gene ID
64121
UniProt ID
Q9HB90
Alternative Names
Ras Related GTP Binding C; GTPase-Interacting Protein 2; TIB929; RAGC; Ras-Related GTP-Binding Protein C; Ras-Related GTP Binding C; Rag C Protein; Rag C; GTR2;
Function
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279).
Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279).
This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279).
Biological Process
Biological Process apoptotic process1 PublicationNAS:UniProtKB
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusISS:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationISS:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to amino acidManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA splicing1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Lysosome
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942).
Involvement in disease
RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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