Mouse Anti-RRAGC Recombinant Antibody (9j75) (CBMAB-R3639-CN)

Name: Mouse Anti-RRAGC Recombinant Antibody (9j75)
SKU: CBMAB-R3639-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

9j75

Application

Dot, WB

Immunogen

Partial recombinant sequence corresponding to the N-terminal region of human RRAGC

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4, 1% BSA

Preservative

0.05% Sodium azide

Concentration

0.1 mg/mL

Epitope

N-term

More Infomation

Target

Full Name

Ras Related GTP Binding C

Introduction

This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Entrez Gene ID

64121

UniProt ID

Q9HB90

Alternative Names

Ras Related GTP Binding C; GTPase-Interacting Protein 2; TIB929; RAGC; Ras-Related GTP-Binding Protein C; Ras-Related GTP Binding C; Rag C Protein; Rag C; GTR2;

Function

Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:20381137, PubMed:27234373, PubMed:24095279).
Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form (PubMed:24095279).
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:20381137, PubMed:27234373, PubMed:24095279).
This is a crucial step in the activation of the TOR signaling cascade by amino acids (PubMed:20381137, PubMed:27234373, PubMed:24095279).

Biological Process

Biological Process apoptotic process1 PublicationNAS:UniProtKB
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process cellular response to amino acid stimulusISS:UniProtKB
Biological Process cellular response to starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein localizationISS:UniProtKB
Biological Process regulation of autophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of TOR signalingManual Assertion Based On ExperimentIGI:UniProtKB
Biological Process regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to amino acidManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process RNA splicing1 PublicationNAS:UniProtKB
Biological Process small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Lysosome
Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942).

Involvement in disease

RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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