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S100A4

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Full Name

S100 Calcium Binding Protein A4

Function

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770).
Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441).
Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity).
Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197).
Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity).
In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597).

Biological Process

Biological Process epithelial to mesenchymal transitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Nucleus
Cytoplasm

Anti-S100A4 antibodies

Mouse Anti-S100A4 Antibody (11BA18) (CBMAB-1546CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 11BA18

Application*: P, IH

Mouse Anti-S100A4 Antibody (11BA17) (CBMAB-1545CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 11BA17

Application*: E, P, IH, M, WB

Mouse Anti-S100A4 Antibody (11BA16) (CBMAB-1544CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 11BA16

Application*: E, P, IH, M

Mouse Anti-S100A4 Recombinant Antibody (CBXF-2493) (CBMAB-F2980-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBXF-2493

Application*: IF, P, WB, F

Rabbit Anti-S100A4 Recombinant Antibody (CBXS-5455) (CBMAB-S2665-CQ)

SDS

Target: S100A4

Host: Rabbit

Specificity: Human, Mouse

Clone: CBXS-5455

Application*: WB, IP, P

Mouse Anti-S100A4 Recombinant Antibody (CBXS-6104) (CBMAB-S2938-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-6104

Application*: F, E, IF, WB

Rabbit Anti-S100A4 Recombinant Antibody (CBXS-1461) (CBMAB-S4317-CQ)

SDS

Target: S100A4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1461

Application*: WB, IP, P, F, IF

Mouse Anti-S100A4 Recombinant Antibody (CBFYA-0275) (CBMAB-X0403-FY)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Horse, Rabbit, Sheep

Clone: CBFYA-0275

Application*: FN, IA, WB

Recombinant Mouse Anti-S100A4 Antibody (CBHb344) (CBMAB-Hb942-LY)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cat, Dog, Rabbit, Sheep

Clone: CBHb344

Application*: FuncS, Immuno assays, IHC-P, WB

Recombinant Mouse Anti-S100A4 Recombinant Antibody (4B4) (CBMAB-XB1016-YC)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgM

Specificity: Human, Pig, Rat

Clone: 4B4

Application*: E, IF, WB

Recombinant Mouse Anti-S100A4 Antibody (CBHb340) (CBMAB-Hb941-LY)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Horse, Rabbit, Sheep

Clone: CBHb340

Application*: FuncS, Immuno assays, WB

Rabbit Anti-S100A4 Recombinant Antibody (D9F9D) (CBMAB-CP2331-LY)

SDS

Target: S100A4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: D9F9D

Application*: WB, IP, P

Mouse Anti-S100A4 Recombinant Antibody (CBXF-2494) (CBMAB-F1353-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2494

Application*: WB, IP

Mouse Anti-S100A4 Recombinant Antibody (CBXS-3923) (CBMAB-S0163-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2b, λ

Specificity: Human

Clone: CBXS-3923

Application*: WB, IH, IF, P

Mouse Anti-S100A4 Recombinant Antibody (CBXS-4102) (CBMAB-S0229-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBXS-4102

Application*: WB, IH, IF, P

Mouse Anti-S100A4 Recombinant Antibody (S100A4/1481) (CBMAB-S0348-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: S100A4/1481

Application*: WB, F, IF, P, MC

Mouse Anti-S100A4 Recombinant Antibody (S100A4/1482) (CBMAB-S0349-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: S100A4/1482

Application*: WB, F, IF, P, MC

Mouse Anti-S100A4 Recombinant Antibody (CBXS-3914) (CBMAB-S1182-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: CBXS-3914

Application*: WB, F, E, IF

Mouse Anti-S100A4 Recombinant Antibody (CBXS-4618) (CBMAB-S1858-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBXS-4618

Application*: E, IF, IH, WB

Mouse Anti-S100A4 Recombinant Antibody (CBXS-5302) (CBMAB-S2516-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5302

Application*: WB, IH, P

Mouse Anti-S100A4 Recombinant Antibody (CBXS-5303) (CBMAB-S2517-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXS-5303

Application*: WB, IH, P

Mouse Anti-S100A4 Recombinant Antibody (CBXS-5304) (CBMAB-S2518-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-5304

Application*: WB, IH, IF, P, ID

Mouse Anti-S100A4 Recombinant Antibody (CBXS-0079) (CBMAB-S3079-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-0079

Application*: E, F

Mouse Anti-S100A4 Recombinant Antibody (CBXS-0080) (CBMAB-S3080-CQ)

SDS

Target: S100A4

Host: Mouse

Specificity: Human

Clone: CBXS-0080

Application*: WB, IC, P, C, E

Rabbit Anti-S100A4 Recombinant Antibody (CBXS-1387) (CBMAB-S4245-CQ)

SDS

Target: S100A4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1387

Application*: WB, IP, P, IF

Rat Anti-S100A4 Recombinant Antibody (CBXS-1828) (CBMAB-S4634-CQ)

SDS

Target: S100A4

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXS-1828

Application*: WB

Mouse Anti-S100A4 Recombinant Antibody (CBXS-1980) (CBMAB-S4750-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXS-1980

Application*: WB, IH, IC

Mouse Anti-S100A4 Recombinant Antibody (CBXS-2778) (CBMAB-S5529-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBXS-2778

Application*: E, IF, WB

Mouse Anti-S100A4 Recombinant Antibody (CBXS-3479) (CBMAB-S6209-CQ)

SDS

Target: S100A4

Host: Mouse

Specificity: Human

Clone: CBXS-3479

Application*: E, F

Mouse Anti-S100A4 Recombinant Antibody (NJ4F3) (CBMAB-S6454-CQ)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: NJ4F3

Application*: E, F, IF, cE

Mouse Anti-S100A4 Recombinant Antibody (3D10-B4-D10) (CBMAB-Z0322-LY)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3D10-B4-D10

Application*: WB, IP

Mouse Anti-S100A4 Recombinant Antibody (1F12-1G7) (CBMAB-A7861-LY)

SDS

Target: S100A4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 1F12-1G7

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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