Human Recombinant S100A4 protein, hFc Tag (V2LY-0526-LY6649)

Name: Human Recombinant S100A4 protein, hFc Tag
SKU: V2LY-0526-LY6649
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant S100A4 protein, hFc Tag consist of Amino Acid: 1-101 and predicts a molecular mass of 38.4 kDa.

Molecule Mass

38.4 kDa

Sequence

Amino Acid: 1-101

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

S100 Calcium Binding Protein A4

Alternative Names

S100 Calcium Binding Protein A4; S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog); Placental Calcium-Binding Protein; Fibroblast-Specific Protein-1; Protein Mts1; MTS1; CAPL; S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog); Leukemia Multidrug Resistance Associated Protein; Malignant Transformation Suppression 1;

Function

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770).
Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441).
Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity).
Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197).
Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity).
In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597).

Biological Process

Biological Process epithelial to mesenchymal transitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Nucleus
Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant S100A4 protein (CAT#: V2LY-0526-LY8857)

Mouse Recombinant S100A4 protein, hFc Tag (CAT#: V2LY-0526-LY8858)

Mouse Recombinant S100A4 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY8859)

Human Recombinant S100A4 protein, His Tag (CAT#: V2LY-0526-LY6650)

Human Recombinant S100A4 protein, Biotin Conjugated, His Tag (CAT#: V2LY-0526-LY6651)

Mouse Recombinant S100A4 protein, His Tag (CAT#: V2LY-0526-LY8860)

Rat S100a4 ELISA Kit (CAT#: V2LY-0626-LY1576)

Mouse S100a4 ELISA Kit (CAT#: V2LY-0626-LY2935)

Human S100A4 ELISA Kit (CAT#: V2LY-0626-LY5113)

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Human Recombinant S100A4 protein, His Tag (CAT#: V2LY-0526-LY6650)

Mouse Anti-S100A4 Recombinant Antibody (CBXF-2493) (CAT#: CBMAB-F2980-CQ)

Mouse Anti-S100A4 Recombinant Antibody (CBFYA-0275) (CAT#: CBMAB-X0403-FY)

Rabbit Anti-S100A4 Recombinant Antibody (CBXS-5455) (CAT#: CBMAB-S2665-CQ)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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