Mouse Anti-S100A4 Recombinant Antibody (CBXS-2778) (CBMAB-S5529-CQ)

Name: Mouse Anti-S100A4 Recombinant Antibody (CBXS-2778)
SKU: CBMAB-S5529-CQ
Rating: 5 (1 reviews)

See all S100A4 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2778

Application

ELISA, IF, WB

Immunogen

Full length recombinant corresponding to aa1-102 from human S100A4 (AAH16300) with GST tag

Specificity

Human, Mouse

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

S100 Calcium Binding Protein A4

Introduction

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Entrez Gene ID

Human	6275
Mouse	20198

UniProt ID

Human	P26447
Mouse	P07091

Alternative Names

S100 Calcium Binding Protein A4; S100 Calcium-Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog); Placental Calcium-Binding Protein; Fibroblast-Specific Protein-1; Protein Mts1; MTS1; CAPL; S100 Calcium Binding Protein A4 (Calcium Protein, Calvasculin, Metastasin, Murine Placental Homolog); Leukemia Multidrug Resistance Associated Protein; Malignant Transformation Suppression 1;

Function

Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:16707441, PubMed:23752197, PubMed:30713770).
Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:16707441).
Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity).
Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (PubMed:23752197).
Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity).
In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (PubMed:30713770, PubMed:26654597).

Biological Process

Biological Process epithelial to mesenchymal transitionManual Assertion Based On ExperimentTAS:HGNC-UCL
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Nucleus
Cytoplasm

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-S100A4 Recombinant Antibody (CBXS-2778)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-S100A4 Recombinant Antibody (CBXF-2494) (CAT#: CBMAB-F1353-CQ)

Mouse Anti-S100A4 Recombinant Antibody (CBXS-0079) (CAT#: CBMAB-S3079-CQ)

Mouse Anti-S100A4 Recombinant Antibody (CBXS-5304) (CAT#: CBMAB-S2518-CQ)

Mouse Anti-S100A4 Recombinant Antibody (S100A4/1482) (CAT#: CBMAB-S0349-CQ)

Rabbit Anti-S100A4 Recombinant Antibody (CBXS-5455) (CAT#: CBMAB-S2665-CQ)

Mouse Anti-S100A4 Recombinant Antibody (3D10-B4-D10) (CAT#: CBMAB-Z0322-LY)

Mouse Anti-S100A4 Recombinant Antibody (CBT2105) (CAT#: V2LY-0625-LY1922)

Mouse Anti-S100A4 Recombinant Antibody (CBXF-2493) (CAT#: CBMAB-F2980-CQ)

Mouse Anti-S100A4 Recombinant Antibody (CBFYA-0275) (CAT#: CBMAB-X0403-FY)

Mouse Anti-S100A4 Recombinant Antibody (EC223) (CAT#: V2LY-0624-LY223)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry