SAMM50
SAMM50 is a component of the sorting and assembly machinery (SAM) complex of the outer mitochondrial membrane. The SAM complex has a role in integrating beta-barrel proteins into the outer mitochondrial membrane (Humphries et al., 2005 [PubMed 15644312]).[supplied by OMIM
Full Name
sorting and assembly machinery component 50 homolog (S. cerevisiae)
Function
Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes (PubMed:22252321, PubMed:25781180).
Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312).
Required for the assembly of TOMM40 into the TOM complex (PubMed:15644312).
Biological Process
Biological Process cristae formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process inner mitochondrial membrane organization1 PublicationIC:UniProtKB
Biological Process mitochondrial respiratory chain complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein insertion into mitochondrial outer membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process inner mitochondrial membrane organization1 PublicationIC:UniProtKB
Biological Process mitochondrial respiratory chain complex assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein insertion into mitochondrial outer membraneManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Mitochondrion outer membrane
Cytoplasm
Mitochondrion
Cytoplasm
Mitochondrion
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Anti-SAMM50 antibodies
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Target: SAMM50
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2A9
Application*: WB, E
Target: SAMM50
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBXS-1614
Application*: WB, P, F
Target: SAMM50
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0120
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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