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SCGB3A2

In addition to regulating thyroid-specific expression of genes, thyroid transcription factor (TITF1; MIM 600635) controls the transcription of genes specifically expressed in lung, such as surfactant proteins (e.g., SFTPA1; MIM 178630) and uteroglobin (UGB; MIM 192020). Mice lacking Ttf1 die immediately after birth from respiratory failure caused by profoundly hypoplastic lungs (Kimura et al., 1996 [PubMed 8557195]). The UGRP1 gene encodes a uteroglobin-related protein and is a downstream target of TITF1.[supplied by OMIM

Full Name

secretoglobin, family 3A, member 2

Function

Secreted cytokine-like protein (PubMed:12847263).
Binds to the scavenger receptor MARCO (PubMed:12847263).
Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263).
Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919).
Seems to have anti-inflammatory effects in respiratory epithelium (By similarity).
Also has anti-fibrotic activity in lung (PubMed:24213919).
May play a role in fetal lung development and maturation (PubMed:24213919).
Promotes branching morphogenesis during early stages of lung development (PubMed:24213919).
In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).

Cellular Location

Secreted

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Anti-SCGB3A2 antibodies

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Rat Anti-SCGB3A2 Recombinant Antibody (381707) (CBMAB-C4235-CN)

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Target: SCGB3A2

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 381707

Application*: WB

Mouse Anti-SCGB3A2 Recombinant Antibody (1B2) (CBMAB-C4234-CN)

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Target: SCGB3A2

Host: Mouse

Specificity: human

Clone: 1B2

Application*: WB, IP, E

Mouse Anti-SCGB3A2 Recombinant Antibody (CBXS-2692) (CBMAB-S5444-CQ)

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Target: SCGB3A2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-2692

Application*: E, WB

Rabbit Anti-SCGB3A2 Recombinant Antibody (CBXS-1281) (CBMAB-S4140-CQ)

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Target: SCGB3A2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXS-1281

Application*: WB, IF

Rat Anti-SCGB3A2 Recombinant Antibody (CBLXU-163) (CBMAB-U0122-CQ)

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Target: SCGB3A2

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBLXU-163

Application*: E, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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