SCGB3A2

In addition to regulating thyroid-specific expression of genes, thyroid transcription factor (TITF1; MIM 600635) controls the transcription of genes specifically expressed in lung, such as surfactant proteins (e.g., SFTPA1; MIM 178630) and uteroglobin (UGB; MIM 192020). Mice lacking Ttf1 die immediately after birth from respiratory failure caused by profoundly hypoplastic lungs (Kimura et al., 1996 [PubMed 8557195]). The UGRP1 gene encodes a uteroglobin-related protein and is a downstream target of TITF1.[supplied by OMIM
Full Name
secretoglobin, family 3A, member 2
Function
Secreted cytokine-like protein (PubMed:12847263).
Binds to the scavenger receptor MARCO (PubMed:12847263).
Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast (PubMed:12847263).
Strongly inhibits phospholipase A2 (PLA2G1B) activity (PubMed:24213919).
Seems to have anti-inflammatory effects in respiratory epithelium (By similarity).
Also has anti-fibrotic activity in lung (PubMed:24213919).
May play a role in fetal lung development and maturation (PubMed:24213919).
Promotes branching morphogenesis during early stages of lung development (PubMed:24213919).
In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) (By similarity).
Cellular Location
Secreted
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Anti-SCGB3A2 antibodies

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Rat Anti-SCGB3A2 Recombinant Antibody (381707) (CBMAB-C4235-CN)

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Target: SCGB3A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 381707
Application*: WB
Datasheet SDS

Mouse Anti-SCGB3A2 Recombinant Antibody (1B2) (CBMAB-C4234-CN)

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Target: SCGB3A2
Host: Mouse
Specificity: human
Clone: 1B2
Application*: WB, IP, E
Datasheet SDS

Mouse Anti-SCGB3A2 Recombinant Antibody (CBXS-2692) (CBMAB-S5444-CQ)

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Target: SCGB3A2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2692
Application*: E, WB
Datasheet SDS

Rabbit Anti-SCGB3A2 Recombinant Antibody (CBXS-1281) (CBMAB-S4140-CQ)

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Target: SCGB3A2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1281
Application*: WB, IF
Datasheet SDS

Rat Anti-SCGB3A2 Recombinant Antibody (CBLXU-163) (CBMAB-U0122-CQ)

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Target: SCGB3A2
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBLXU-163
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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