SDCBP2

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031.

Full Name

Syndecan Binding Protein 2

Function

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).

Biological Process

Biological Process cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process intracellular transport1 PublicationNAS:UniProtKB
Biological Process nervous system development1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Cell membrane
Nucleus speckle
Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519).
Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519).
Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997).
PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).