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Mouse Anti-SDCBP2 Recombinant Antibody (CBXS-0170) (CBMAB-S3156-CQ)

This product is a mouse antibody that recognizes SDCBP2. The antibody CBXS-0170 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all SDCBP2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0170
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Syntenin 2
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Syndecan Binding Protein 2
Introduction
The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031.
Entrez Gene ID
27111
UniProt ID
Q9H190
Alternative Names
Syndecan Binding Protein 2; Syndecan Binding Protein (Syntenin) 2; Syntenin-2; SITAC18; SITAC; Syndecan-Binding Protein 2; Similar To TACIP18; ST-2; ST2;
Function
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
Biological Process
Biological Process cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process intracellular transport1 PublicationNAS:UniProtKB
Biological Process nervous system development1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Cell membrane
Nucleus speckle
Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519).
Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519).
Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997).
PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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