Mouse Anti-SDCBP2 Recombinant Antibody (CBXS-3508) (CBMAB-S6237-CQ)

Name: Mouse Anti-SDCBP2 Recombinant Antibody (CBXS-3508)
SKU: CBMAB-S6237-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXS-3508

Application

ELISA, WB

Immunogen

Recombinant human Syntenin-2 with a GST tag

Specificity

Human, Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Syndecan Binding Protein 2

Introduction

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031.

Entrez Gene ID

Human	27111
Mouse	228765

UniProt ID

Human	Q9H190
Mouse	Q99JZ0

Alternative Names

Syndecan Binding Protein 2; Syndecan Binding Protein (Syntenin) 2; Syntenin-2; SITAC18; SITAC; Syndecan-Binding Protein 2; Similar To TACIP18; ST-2; ST2;

Function

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).

Biological Process

Biological Process cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular signal transduction1 PublicationNAS:UniProtKB
Biological Process intracellular transport1 PublicationNAS:UniProtKB
Biological Process nervous system development1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm
Nucleus, nucleolus
Nucleus, nucleoplasm
Cell membrane
Nucleus speckle
Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519).
Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519).
Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997).
PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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