SEMA5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene.

Semaphorin 5B

May act as positive axonal guidance cues.

Biological Process axon extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process detection of light stimulus involved in visual perceptionIEA:Ensembl
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Membrane

Extracellular: 1-1036
Helical: 1037-1057
Cytoplasmic: 1058-1151