SEMA5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Semaphorin 5B

Function

May act as positive axonal guidance cues.

Biological Process

Biological Process axon extensionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process detection of light stimulus involved in visual perceptionIEA:Ensembl
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Membrane

Topology

Extracellular: 1-1036
Helical: 1037-1057
Cytoplasmic: 1058-1151