SEPSECS

The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

Full Name

Sep (O-Phosphoserine) TRNA:Sec (Selenocysteine) TRNA Synthase

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Biological Process

Biological Process selenocysteine incorporationISS:HGNC-UCL
Biological Process selenocysteinyl-tRNA(Sec) biosynthetic processIEA:UniProtKB-UniPathway

Cellular Location

Cytoplasm

Involvement in disease

Pontocerebellar hypoplasia 2D (PCH2D):
A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound intellectual disability, spasticity, and variable seizures.

Anti-SEPSECS antibodies

Mouse Anti-SEPSECS Recombinant Antibody (EP-1) (CBMAB-H3807-FY)

Datasheet

SDS

Target: SEPSECS

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: EP-1

Application*: C, P

Mouse Anti-SEPSECS Recombinant Antibody (CBXS-2165) (CBMAB-S4928-CQ)

Datasheet

SDS

Target: SEPSECS

Host: Mouse

Specificity: Human

Clone: CBXS-2165

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)