SESN3

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

Full Name

sestrin 3

Function

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562).
May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity).
This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).

Biological Process

Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose homeostasisIEA:Ensembl
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of macroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process regulation of protein kinase B signalingIEA:Ensembl
Biological Process regulation of response to reactive oxygen speciesIEA:InterPro
Biological Process response to insulinIEA:Ensembl
Biological Process TORC2 signalingIEA:Ensembl

Cellular Location

Cytoplasm