Mouse Anti-SESN3 Recombinant Antibody (CBXS-4470) (CBMAB-S1712-CQ)

Name: Mouse Anti-SESN3 Recombinant Antibody (CBXS-4470)
SKU: CBMAB-S1712-CQ
Rating: 5 (1 reviews)

See all SESN3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-4470

Application

WB, IP, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sestrin 3

Introduction

This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

143686

UniProt ID

P58005

Alternative Names

Sestrin 3; SEST3; Sestrin-3;

Function

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562).
May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity).
This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).

Biological Process

Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose homeostasisIEA:Ensembl
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of macroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process regulation of protein kinase B signalingIEA:Ensembl
Biological Process regulation of response to reactive oxygen speciesIEA:InterPro
Biological Process response to insulinIEA:Ensembl
Biological Process TORC2 signalingIEA:Ensembl

Cellular Location

Cytoplasm

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SESN3 Recombinant Antibody (CBXS-4470)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SESN3 Recombinant Antibody (2C9) (CAT#: CBMAB-A8014-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry