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Mouse Anti-SESN3 Recombinant Antibody (CBXS-4470) (CBMAB-S1712-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4470
Application
WB, IP, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sestrin 3
Introduction
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
143686
UniProt ID
P58005
Alternative Names
Sestrin 3; SEST3; Sestrin-3;
Function
May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562).
May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity).
This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity).
Biological Process
Biological Process cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process cellular response to leucineManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leucine starvationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process glucose homeostasisIEA:Ensembl
Biological Process negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of macroautophagyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of insulin receptor signaling pathwayIEA:Ensembl
Biological Process regulation of protein kinase B signalingIEA:Ensembl
Biological Process regulation of response to reactive oxygen speciesIEA:InterPro
Biological Process response to insulinIEA:Ensembl
Biological Process TORC2 signalingIEA:Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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