SEZ6
The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures.
Full Name
Seizure Related 6 Homolog
Function
May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).
Biological Process
Biological Process adult locomotory behaviorIEA:Ensembl
Biological Process cerebellar Purkinje cell layer developmentIEA:Ensembl
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process regulation of dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein kinase C signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse maturationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cerebellar Purkinje cell layer developmentIEA:Ensembl
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process regulation of dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein kinase C signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse maturationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Localized on dendrites and in the synaptic and postsynaptic fraction.
Localized on dendrites and in the synaptic and postsynaptic fraction.
Topology
Extracellular: 20-925
Helical: 926-946
Cytoplasmic: 947-994
Helical: 926-946
Cytoplasmic: 947-994
PTM
Glycosylated.
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Anti-SEZ6 antibodies
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Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-927
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-923
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-922
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: Fc Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: His & AVI Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-927
Tag: His Tag
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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