SEZ6

The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures.
Full Name
Seizure Related 6 Homolog
Function
May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).
Biological Process
Biological Process adult locomotory behaviorIEA:Ensembl
Biological Process cerebellar Purkinje cell layer developmentIEA:Ensembl
Biological Process excitatory postsynaptic potentialIEA:Ensembl
Biological Process regulation of dendrite developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of protein kinase C signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse maturationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Localized on dendrites and in the synaptic and postsynaptic fraction.
Topology
Extracellular: 20-925
Helical: 926-946
Cytoplasmic: 947-994
PTM
Glycosylated.
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Anti-SEZ6 antibodies

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Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-927
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-923
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-922
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: Fc Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: His Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-925
Tag: His & AVI Tag
Target: SEZ6
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-927
Tag: His Tag
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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