SIRPB1

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Full Name
Signal Regulatory Protein Beta 1
Function
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 30-371
Helical: 372-392
Cytoplasmic: 393-398
PTM
N-glycosylated.
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Anti-SIRPB1 antibodies

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Mouse Anti-SIRPB1 Recombinant Antibody (CBT4801) (V2LY-0625-LY1720)

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Target: SIRPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4801
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-SIRPB1 Recombinant Antibody (CBT4505) (V2LY-0625-LY1719)

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Target: SIRPB1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4505
Application*: F
Datasheet SDS

Mouse Anti-SIRPB1 Recombinant Antibody (B1D5) (CBMAB-S2962-CQ)

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Target: SIRPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: B1D5
Application*: WB, IP, F
Datasheet SDS

Mouse Anti-SIRPB1 Recombinant Antibody (CBXS-1763) (CBMAB-S0111-CQ)

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Target: SIRPB1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-1763
Application*: F
Datasheet SDS

Mouse Anti-SIRPB1 Recombinant Antibody (B4B6) (CBMAB-C1719-CQ)

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Target: SIRPB1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: B4B6
Application*: F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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