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Mouse Anti-SIRPB1 Recombinant Antibody (B4B6) (CBMAB-C1719-CQ)

This product is a mouse antibody that recognizes SIRPB1. The antibody B4B6 can be used for immunoassay techniques such as: FC.
See all SIRPB1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
B4B6
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Extracellular domain of SIRPβ1 (recombinant fusion protein)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Signal Regulatory Protein Beta 1
Introduction
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10326
UniProt ID
O00241
Alternative Names
Signal Regulatory Protein Beta 1; CD172 Antigen-Like Family Member B; SIRP-BETA-1; Signal-Regulatory Protein Beta 1; Signal-Regulatory Protein Beta-1; SIRP-Beta-1 Isoform 3; CD172b Antigen; CD172b;
Function
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985).
Biological Process
Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 30-371
Helical: 372-392
Cytoplasmic: 393-398
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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