Mouse Anti-SIRPB1 Recombinant Antibody (B1D5) (CBMAB-S2962-CQ)

Name: Mouse Anti-SIRPB1 Recombinant Antibody (B1D5)
SKU: CBMAB-S2962-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

B1D5

Application

WB, IP, FC

Specificity

Human

Antibody Isotype

IgG2a

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

2.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Signal Regulatory Protein Beta 1

Introduction

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

10326

UniProt ID

O00241

Alternative Names

Signal Regulatory Protein Beta 1; CD172 Antigen-Like Family Member B; SIRP-BETA-1; Signal-Regulatory Protein Beta 1; Signal-Regulatory Protein Beta-1; SIRP-Beta-1 Isoform 3; CD172b Antigen; CD172b;

Function

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985).

Biological Process

Biological Process cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Biological Process positive regulation of phagocytosisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of T cell activationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 30-371
Helical: 372-392
Cytoplasmic: 393-398

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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