SLC30A8

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Full Name

solute carrier family 30 (zinc transporter), member 8

Function

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Biological Process

Biological Process cellular zinc ion homeostasisISS:BHF-UCL
Biological Process insulin processingTAS:Reactome
Biological Process insulin secretionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of insulin secretionISS:BHF-UCL
Biological Process regulation of sequestering of zinc ionISS:BHF-UCL
Biological Process regulation of vesicle-mediated transportISS:BHF-UCL
Biological Process response to glucoseManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to interferon-gammaIEA:Ensembl
Biological Process response to interleukin-1IEA:Ensembl
Biological Process response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sequestering of zinc ionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transportManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cell membrane
Cytoplasmic vesicle, secretory vesicle membrane
Associated with insulin and glucagon secretory granules.

Topology

Cytoplasmic: 1-79
Helical: 80-100
Extracellular: 101-103
Helical: 104-124
Cytoplasmic: 125-140
Helical: 141-161
Extracellular: 162-175
Helical: 176-196
Cytoplasmic: 197-217
Helical: 218-238
Extracellular: 239-245
Helical: 246-266
Cytoplasmic: 267-369