Mouse Anti-SLC30A8 Recombinant Antibody (815039) (CBMAB-Z0701-WJ)

Name: Mouse Anti-SLC30A8 Recombinant Antibody (815039)
SKU: CBMAB-Z0701-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

815039

Application

IHC

Immunogen

E. coli-derived recombinant human ZnT-8, Lys268-Pro359.

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Solid

More Infomation

Target

Full Name

solute carrier family 30 (zinc transporter), member 8

Introduction

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

169026

UniProt ID

Q8IWU4

Alternative Names

ZNT8; ZnT-8

Function

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Biological Process

Biological Process cellular zinc ion homeostasisISS:BHF-UCL
Biological Process insulin processingTAS:Reactome
Biological Process insulin secretionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of insulin secretionISS:BHF-UCL
Biological Process regulation of sequestering of zinc ionISS:BHF-UCL
Biological Process regulation of vesicle-mediated transportISS:BHF-UCL
Biological Process response to glucoseManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to interferon-gammaIEA:Ensembl
Biological Process response to interleukin-1IEA:Ensembl
Biological Process response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sequestering of zinc ionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transportManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cell membrane
Cytoplasmic vesicle, secretory vesicle membrane
Associated with insulin and glucagon secretory granules.

Topology

Cytoplasmic: 1-79
Helical: 80-100
Extracellular: 101-103
Helical: 104-124
Cytoplasmic: 125-140
Helical: 141-161
Extracellular: 162-175
Helical: 176-196
Cytoplasmic: 197-217
Helical: 218-238
Extracellular: 239-245
Helical: 246-266
Cytoplasmic: 267-369

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Human SLC30A8 ELISA Kit (CAT#: V2LY-0626-LY3816)

Mouse Anti-SLC30A8 Recombinant Antibody (CBWJZ-266) (CAT#: CBMAB-Z0702-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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