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Mouse Anti-SLC30A8 Recombinant Antibody (815039) (CBMAB-Z0701-WJ)

This product is a mouse antibody that recognizes SLC30A8. The antibody 815039 can be used for immunoassay techniques such as: IHC.
See all SLC30A8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
815039
Antibody Isotype
IgG2b
Application
IHC

Basic Information

Immunogen
E. coli-derived recombinant human ZnT-8, Lys268-Pro359.
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Solid

Target

Full Name
solute carrier family 30 (zinc transporter), member 8
Introduction
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
ZNT8; ZnT-8
Function
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
Biological Process
Biological Process cellular zinc ion homeostasisISS:BHF-UCL
Biological Process insulin processingTAS:Reactome
Biological Process insulin secretionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of insulin secretionISS:BHF-UCL
Biological Process regulation of sequestering of zinc ionISS:BHF-UCL
Biological Process regulation of vesicle-mediated transportISS:BHF-UCL
Biological Process response to glucoseManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process response to interferon-gammaIEA:Ensembl
Biological Process response to interleukin-1IEA:Ensembl
Biological Process response to zinc ionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sequestering of zinc ionManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process zinc ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process zinc ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cell membrane
Cytoplasmic vesicle, secretory vesicle membrane
Associated with insulin and glucagon secretory granules.
Topology
Cytoplasmic: 1-79
Helical: 80-100
Extracellular: 101-103
Helical: 104-124
Cytoplasmic: 125-140
Helical: 141-161
Extracellular: 162-175
Helical: 176-196
Cytoplasmic: 197-217
Helical: 218-238
Extracellular: 239-245
Helical: 246-266
Cytoplasmic: 267-369
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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