SMAD5

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

SMAD Family Member 5

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process bone developmentIEA:Ensembl
Biological Process cardiac conduction system development1 PublicationNAS:BHF-UCL
Biological Process cardiac muscle contractionIEA:Ensembl
Biological Process cartilage developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process embryonic pattern specificationISS:UniProtKB
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process germ cell developmentIEA:Ensembl
Biological Process Mullerian duct regressionIEA:Ensembl
Biological Process osteoblast fate commitmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS:BHF-UCL
Biological Process protein phosphorylationIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:UniProtKB
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ureteric bud developmentIEA:Ensembl

Cytoplasm
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.