SMAD5
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Full Name
SMAD Family Member 5
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process bone developmentIEA:Ensembl
Biological Process cardiac conduction system development1 PublicationNAS:BHF-UCL
Biological Process cardiac muscle contractionIEA:Ensembl
Biological Process cartilage developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process embryonic pattern specificationISS:UniProtKB
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process germ cell developmentIEA:Ensembl
Biological Process Mullerian duct regressionIEA:Ensembl
Biological Process osteoblast fate commitmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS:BHF-UCL
Biological Process protein phosphorylationIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:UniProtKB
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ureteric bud developmentIEA:Ensembl
Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process bone developmentIEA:Ensembl
Biological Process cardiac conduction system development1 PublicationNAS:BHF-UCL
Biological Process cardiac muscle contractionIEA:Ensembl
Biological Process cartilage developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process embryonic pattern specificationISS:UniProtKB
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process germ cell developmentIEA:Ensembl
Biological Process Mullerian duct regressionIEA:Ensembl
Biological Process osteoblast fate commitmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS:BHF-UCL
Biological Process protein phosphorylationIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:UniProtKB
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ureteric bud developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
PTM
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
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Anti-SMAD5 antibodies
Products List
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Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Rat, Mouse
Clone: CB07A
Application*: ELISA, WB, ICC, FC
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D4G2
Application*: WB, IP, CI
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F10
Application*: WB, E
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3A10
Application*: WB, E
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D7
Application*: WB, E
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1C1
Application*: WB, E
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5E12
Application*: WB, E
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Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-198
Application*: E, IH
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Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-197
Application*: E, WB
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: WB, P, IF/IC
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: ZS004
Application*: E, F, IC, IF, P, WB
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: MMC-1-104-3
Application*: WB, P, IC
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-3292
Application*: E, WB
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-3222
Application*: E, WB
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-2995
Application*: E, IF, WB
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-2707
Application*: E, WB
Target: SMAD5
Host: Mouse
Specificity: Human, Mouse
Clone: CBXS-2598
Application*: F, IC, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2510
Application*: F, IC, WB
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: CBXS-2490
Application*: IP, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-2450
Application*: E, F, IH, WB
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1225
Application*: WB, IF
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human, Monkey
Clone: CBXS-1221
Application*: WB, P, IC, F
Target: SMAD5
Host: Mouse
Specificity: Human, Pig, Rat, Mouse
Clone: CBXS-0528
Application*: WB, IC, F
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-0527
Application*: IC, IF, IH, WB
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-0526
Application*: F, IC, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-0525
Application*: E, IF, WB
Target: SMAD5
Host: Mouse
Specificity: Human
Clone: CBXS-0524
Application*: F, IC, IF, WB
Target: SMAD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBXS-0523
Application*: WB, P, IF, F
Target: SMAD5
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: CBXS-0522
Application*: WB, IH, IF
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-0521
Application*: SE, E, WB, IF
Target: SMAD5
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXS-5397
Application*: WB, IP, CI
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBXS-4950
Application*: F, IC, IF, IH, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4503
Application*: E, IF, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXS-5670
Application*: F, IF, WB
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Pig, Rat, Mouse
Clone: 14E2
Application*: E, WB, IC, F
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBT1137
Application*: WB, P, IF, IC, F, E
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Cattle, Chicken, Pig, Sheep
Clone: CBT1138
Application*: WB, IF, IC, F
Target: SMAD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: CBT4231
Application*: WB, IH, IC, F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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