Rabbit Anti-SMAD5 Recombinant Antibody (CBXS-2490) (CBMAB-S5247-CQ)

Name: Rabbit Anti-SMAD5 Recombinant Antibody (CBXS-2490)
SKU: CBMAB-S5247-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-2490

Application

IP, WB

Immunogen

Synthetic peptide corresponding to residues surrounding Pro249 of human Smad5

Specificity

Human, Monkey, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 0.1 mg/mL BSA, 50% glycerol

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SMAD Family Member 5

Introduction

The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	4090
Mouse	17129
Rat	59328
Monkey	712645

UniProt ID

Human	Q99717
Mouse	P97454
Rat	Q9R1V3
Monkey	F6YMS3

Alternative Names

SMAD Family Member 5; MADH5; JV5-1; MAD, Mothers Against Decapentaplegic Homolog 5 (Drosophila); Mothers Against Decapentaplegic, Drosophila, Homolog Of, 5; SMAD, Mothers Against DPP Homolog 5 (Drosophila); MAD, Mothers Against Decapentaplegic Homolog 5; Mothers Against Decapentaplegic Homolog 5; SMAD, Mothers Against DPP Homolog 5;

Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Biological Process

Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process bone developmentIEA:Ensembl
Biological Process cardiac conduction system development1 PublicationNAS:BHF-UCL
Biological Process cardiac muscle contractionIEA:Ensembl
Biological Process cartilage developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process embryonic pattern specificationISS:UniProtKB
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process germ cell developmentIEA:Ensembl
Biological Process Mullerian duct regressionIEA:Ensembl
Biological Process osteoblast fate commitmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS:BHF-UCL
Biological Process protein phosphorylationIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:UniProtKB
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ureteric bud developmentIEA:Ensembl

Cellular Location

Cytoplasm
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

PTM

Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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