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Mouse Anti-SMAD5 Recombinant Antibody (CBXS-3222) (CBMAB-S5963-CQ)

This product is a mouse antibody that recognizes SMAD5. The antibody CBXS-3222 can be used for immunoassay techniques such as: ELISA, WB.
See all SMAD5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3222
Application
ELISA, WB

Basic Information

Immunogen
SMAD5 (AAH09682, 105aa-182aa) partial recombinant protein with GST tag
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SMAD Family Member 5
Introduction
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4090
UniProt ID
Q99717
Alternative Names
SMAD Family Member 5; MADH5; JV5-1; MAD, Mothers Against Decapentaplegic Homolog 5 (Drosophila); Mothers Against Decapentaplegic, Drosophila, Homolog Of, 5; SMAD, Mothers Against DPP Homolog 5 (Drosophila); MAD, Mothers Against Decapentaplegic Homolog 5; Mothers Against Decapentaplegic Homolog 5; SMAD, Mothers Against DPP Homolog 5;
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Biological Process
Biological Process anatomical structure morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process BMP signaling pathwayISS:UniProtKB
Biological Process bone developmentIEA:Ensembl
Biological Process cardiac conduction system development1 PublicationNAS:BHF-UCL
Biological Process cardiac muscle contractionIEA:Ensembl
Biological Process cartilage developmentIEA:Ensembl
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to organic cyclic compoundIEA:Ensembl
Biological Process embryonic pattern specificationISS:UniProtKB
Biological Process erythrocyte differentiationIEA:Ensembl
Biological Process germ cell developmentIEA:Ensembl
Biological Process Mullerian duct regressionIEA:Ensembl
Biological Process osteoblast fate commitmentIEA:Ensembl
Biological Process positive regulation of DNA-templated transcription1 PublicationNAS:UniProtKB
Biological Process positive regulation of osteoblast differentiationIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulusISS:BHF-UCL
Biological Process protein phosphorylationIEA:Ensembl
Biological Process signal transduction1 PublicationNAS:UniProtKB
Biological Process SMAD protein signal transductionISS:BHF-UCL
Biological Process transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ureteric bud developmentIEA:Ensembl
Cellular Location
Cytoplasm
Nucleus
Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
PTM
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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