SNCB

This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Full Name
Synuclein Beta
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dopamine metabolic processIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
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Anti-SNCB antibodies

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Rabbit Anti-SNCB Recombinant Antibody (EP1537Y) (CBMAB-1819-CN)

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Target: SNCB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EP1537Y
Application*: IF, WB, IP, P
Datasheet SDS

Human Recombinant SNCB protein, His Tag (V2LY-0526-LY2349)

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Target: SNCB
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

SNCB Matched Antibody Pair (1112) (APMAB-1112LY)

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Target: SNCB
Specificity: Human
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (4F11) (CBMAB-A8420-LY)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F11
Application*: WB, E
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (3H4) (CBMAB-A8419-LY)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H4
Application*: WB, E
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (CBXS-0609) (CBMAB-S3551-CQ)

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Target: SNCB
Host: Mouse
Specificity: Human
Clone: CBXS-0609
Application*: WB
Datasheet SDS

Mouse Anti-SNCB (AA 47-120) Recombinant Antibody (CBXS-0608) (CBMAB-S3550-CQ)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-0608
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (CBXS-4923) (CBMAB-S2145-CQ)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-4923
Application*: E, WB
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (516505) (CBMAB-1821-CN)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 516505
Application*: WB, IH
Datasheet SDS

Mouse Anti-SNCB Recombinant Antibody (3G6) (CBMAB-1820-CN)

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Target: SNCB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G6
Application*: WB, E, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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