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Mouse Anti-SNCB (AA 47-120) Recombinant Antibody (CBXS-0608) (CBMAB-S3550-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0608
Antibody Isotype
IgG2b
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 47-120

Target

Introduction
This gene encodes a member of a small family of proteins that inhibit phospholipase D2 and may function in neuronal plasticity. The encoded protein is abundant in lesions of patients with Alzheimer disease. A mutation in this gene was found in individuals with dementia with Lewy bodies. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
6620
UniProt ID
Q16143
Alternative Names
Synuclein Beta; β -Synuclein; Beta-Synuclein;
Function
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dopamine metabolic processIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
PTM
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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