Mouse Anti-SNCB Recombinant Antibody (4F11) (CBMAB-A8420-LY)

Name: Mouse Anti-SNCB Recombinant Antibody (4F11)
SKU: CBMAB-A8420-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F11

Application

WB, ELISA

Immunogen

SNCB (NP_001001502.1, 1 a.a. ~ 65 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Synuclein Beta

Entrez Gene ID

6620

UniProt ID

Q16143

Function

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Biological Process

Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dopamine metabolic processIEA:Ensembl
Biological Process negative regulation of neuron apoptotic processIEA:Ensembl
Biological Process neuron apoptotic processIEA:Ensembl
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

PTM

Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SNCB Matched Antibody Pair (1112) (CAT#: APMAB-1112LY)

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SNCB Matched Antibody Pair (1112) (CAT#: APMAB-1112LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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