SORCS3

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. [provided by RefSeq]

sortilin-related VPS10 domain containing receptor 3

Biological Process learningIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process neuropeptide signaling pathway1 PublicationNAS:UniProtKB
Biological Process regulation of long-term synaptic depressionIEA:Ensembl

Membrane

Lumenal: 34-1125
Helical: 1126-1146
Cytoplasmic: 1147-1222