Mouse Anti-SORCS3 Recombinant Antibody (CBXS-3504) (CBMAB-S6233-CQ)

Name: Mouse Anti-SORCS3 Recombinant Antibody (CBXS-3504)
SKU: CBMAB-S6233-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-3504

Application

ELISA, WB

Immunogen

Partial recombinant human SorCS3 (aa1147-1222) with a GST tag

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

sortilin-related VPS10 domain containing receptor 3

Introduction

This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.

Entrez Gene ID

22986

UniProt ID

Q9UPU3

Alternative Names

Sortilin Related VPS10 Domain Containing Receptor 3; Sortilin-Related VPS10 Domain Containing Receptor 3; VPS10 Domain Receptor Protein SORCS 3 (SORCS3); VPS10 Domain-Containing Receptor SorCS3; KIAA1059; SORCS;

Biological Process

Biological Process learningIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process neuropeptide signaling pathway1 PublicationNAS:UniProtKB
Biological Process regulation of long-term synaptic depressionIEA:Ensembl

Cellular Location

Membrane

Topology

Lumenal: 34-1125
Helical: 1126-1146
Cytoplasmic: 1147-1222

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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