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Rat Anti-SORCS3 Recombinant Antibody (CBXS-1785) (CBMAB-S4602-CQ)

This product is a rat antibody that recognizes SORCS3. The antibody CBXS-1785 can be used for immunoassay techniques such as: WB.
See all SORCS3 antibodies

Summary

Host Animal
Rat
Specificity
Human, Mouse
Clone
CBXS-1785
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
NS0-derived recombinant mouse SorCS3, Ala131-Ser1122, Accession # Q8VI51
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sortilin-related VPS10 domain containing receptor 3
Introduction
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing.
Entrez Gene ID
Human22986
Mouse66673
UniProt ID
HumanQ9UPU3
MouseQ8VI51
Alternative Names
Sortilin Related VPS10 Domain Containing Receptor 3; Sortilin-Related VPS10 Domain Containing Receptor 3; VPS10 Domain Receptor Protein SORCS 3 (SORCS3); VPS10 Domain-Containing Receptor SorCS3; KIAA1059; SORCS;
Biological Process
Biological Process learningIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process neuropeptide signaling pathway1 PublicationNAS:UniProtKB
Biological Process regulation of long-term synaptic depressionIEA:Ensembl
Cellular Location
Membrane
Topology
Lumenal: 34-1125
Helical: 1126-1146
Cytoplasmic: 1147-1222
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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