SOX30

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may be involved in the differentiation of developing male germ cells. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]

Full Name

SRY (sex determining region Y)-box 30

Function

Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711).
Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848).
Binds to its own promoter and activates its own transcription (By similarity).
Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity).
Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711).
Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711).

Biological Process

Biological Process negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process proacrosomal vesicle fusionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process response to corticosteroidManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process spermatid developmentISS:UniProtKB

Cellular Location

Nucleus
Cytoplasm
Enriched at the chromocenter.