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Mouse Anti-SOX30 Monoclonal Antibody (6H1) (CBMAB-1523-YC)

Provided herein is a mouse monoclonal antibody against Human SOX30. The antibody, clone 6H1, can be used for immunoassay techniques, such as ELISA, ICC, IF and WB.
See all SOX30 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6H1
Antibody Isotype
IgG2a, κ
Application
ELISA, ICC, IF, WB

Basic Information

Immunogen
Partial recombinant protein SOX30 (NP_848511, aa 644-754) with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SRY (sex determining region Y)-box 30
Introduction
SOX30 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate which acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Entrez Gene ID
11063
UniProt ID
O94993
Alternative Names
transcription factor SOX-30; SRY (sex determining region Y)-box 30; Sox30 protein type II
Function
Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711).
Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848).
Binds to its own promoter and activates its own transcription (By similarity).
Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity).
Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711).
Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process proacrosomal vesicle fusionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process response to corticosteroidManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process spermatid developmentISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Enriched at the chromocenter.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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