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Mouse Anti-SOX30 Recombinant Antibody (CBXS-2232) (CBMAB-S4994-CQ)

This product is a mouse antibody that recognizes SOX30. The antibody CBXS-2232 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all SOX30 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2232
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SRY (sex determining region Y)-box 30
Introduction
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein acts as a transcriptional regulator when present in a complex with other proteins. It can activate p53 transcription to promote tumor cell apoptosis in lung cancer. The protein may be involved in the differentiation of developing male germ cells. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Entrez Gene ID
11063
UniProt ID
O94993
Alternative Names
SRY-Box 30; SRY (Sex Determining Region Y)-Box 30; SRY Box 30;
Function
Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711).
Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848).
Binds to its own promoter and activates its own transcription (By similarity).
Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity).
Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711).
Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711).
Biological Process
Biological Process negative regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process negative regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Biological Process proacrosomal vesicle fusionISS:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:GO_Central
Biological Process response to corticosteroidManual Assertion Based On ExperimentIEP:UniProtKB
Biological Process spermatid developmentISS:UniProtKB
Cellular Location
Nucleus
Cytoplasm
Enriched at the chromocenter.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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