SPDEF

PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.[supplied by OMIM

Full Name

SAM pointed domain containing ets transcription factor

Function

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.

Biological Process

Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epithelial cell fate commitmentIEA:Ensembl
Biological Process glandular epithelial cell developmentIEA:Ensembl
Biological Process intestinal epithelial cell developmentIEA:Ensembl
Biological Process lung goblet cell differentiationIEA:Ensembl
Biological Process negative regulation of cell fate commitmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell fate commitmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription by RNA polymerase IIIEA:Ensembl

Cellular Location

Nucleus