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Mouse Anti-SPDEF Recombinant Antibody (G-10) (CBMAB-P3684-YC)

Provided herein is a Mouse monoclonal antibody against Human SAM Pointed Domain Containing ETS Transcription Factor. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all SPDEF antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
G-10
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SAM pointed domain containing ets transcription factor
Introduction
SPDEF belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies.
Entrez Gene ID
25803
UniProt ID
O95238
Alternative Names
SAM Pointed Domain Containing ETS Transcription Factor; Prostate Epithelium-Specific Ets Transcription Factor; Prostate-Derived Ets Factor; Prostate-Specific Ets; PDEF; SAM Pointed Domain-Containing Ets Transcription Factor; BA375E1.3; PSE;
Function
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter.
Biological Process
Biological Process cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process epithelial cell fate commitmentIEA:Ensembl
Biological Process glandular epithelial cell developmentIEA:Ensembl
Biological Process intestinal epithelial cell developmentIEA:Ensembl
Biological Process lung goblet cell differentiationIEA:Ensembl
Biological Process negative regulation of cell fate commitmentIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of cell fate commitmentIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transcription by RNA polymerase IIIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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