SPINT2

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.
Full Name
serine peptidase inhibitor, Kunitz type, 2
Function
Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.
Biological Process
Biological Process basement membrane organizationIEA:Ensembl
Biological Process cellular response to BMP stimulusIEA:Ensembl
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of neural precursor cell proliferationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3):
A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.
Topology
Extracellular: 28-197
Helical: 198-218
Cytoplasmic: 219-252
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Anti-SPINT2 antibodies

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Mouse Anti-SPINT2 Recombinant Antibody (CBXS-2867) (CBMAB-S5617-CQ)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-2867
Application*: E, WB
Datasheet SDS

Mouse Anti-SPINT2 Recombinant Antibody (CBXS-2593) (CBMAB-S5349-CQ)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-2593
Application*: N, WB
Datasheet SDS

Rabbit Anti-SPINT2 Recombinant Antibody (CBXS-1161) (CBMAB-S4043-CQ)

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Target: SPINT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXS-1161
Application*: E
Datasheet SDS

Mouse Anti-SPINT2 (AA 28-197) Recombinant Antibody (CBXS-3763) (CBMAB-S1036-CQ)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3763
Application*: E, WB
Datasheet SDS

Rabbit Anti-SPINT2 Recombinant Antibody (CBFYC-0098) (CBMAB-C0115-FY)

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Target: SPINT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0098
Application*: F
Datasheet SDS

Mouse Anti-SPINT2 Recombinant Antibody (CBFYC-0045) (CBMAB-C0052-FY)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0045
Application*: E, F
Datasheet SDS

Mouse Anti-SPINT2 Recombinant Antibody (CBFYH-2781) (CBMAB-H3848-FY)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2781
Application*: WB
Datasheet SDS

Mouse Anti-SPINT2 (AA 28-197) Recombinant Antibody (CBFYH-2780) (CBMAB-H3847-FY)

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Target: SPINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2780
Application*: WB, EC
Datasheet SDS

Rat Anti-SPINT2 Monoclonal Antibody (CBFYH-3308) (CBMAB-H3846-FY)

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Target: SPINT2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBFYH-3308
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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