Mouse Anti-SPINT2 Recombinant Antibody (CBXS-2593) (CBMAB-S5349-CQ)

Name: Mouse Anti-SPINT2 Recombinant Antibody (CBXS-2593)
SKU: CBMAB-S5349-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2593

Application

Neut, WB

Immunogen

Recombinant protein corresponding to human SPINT2 extracellular domain

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

serine peptidase inhibitor, Kunitz type, 2

Introduction

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

10653

UniProt ID

O43291

Alternative Names

Serine Peptidase Inhibitor, Kunitz Type 2; Hepatocyte Growth Factor Activator Inhibitor Type 2; Serine Protease Inhibitor, Kunitz Type, 2; Placental Bikunin; HAI-2; HAI2;

Function

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

Biological Process

Biological Process basement membrane organizationIEA:Ensembl
Biological Process cellular response to BMP stimulusIEA:Ensembl
Biological Process epithelial cell morphogenesis involved in placental branchingIEA:Ensembl
Biological Process establishment or maintenance of cell polarityIEA:Ensembl
Biological Process negative regulation of cell motilityManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cell-cell adhesionManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of neural precursor cell proliferationIEA:Ensembl
Biological Process neural tube closureIEA:Ensembl

Cellular Location

Membrane

Involvement in disease

Diarrhea 3, secretory sodium, congenital, with or without other congenital anomalies (DIAR3):
A disease characterized by life-threatening secretory diarrhea, severe metabolic acidosis and hyponatremia. Hyponatremia is secondary to extraordinarily high fecal sodium loss, with low or normal excretion of urinary sodium, in the absence of infectious, autoimmune and endocrine causes.

Topology

Extracellular: 28-197
Helical: 198-218
Cytoplasmic: 219-252

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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