SRSF5

The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Alternative splicing results in multiple transcript variants.

Serine And Arginine Rich Splicing Factor 5

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.

Biological Process cellular response to insulin stimulusIEA:Ensembl
Biological Process liver regenerationIEA:Ensembl
Biological Process mRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of RNA splicingIEA:Ensembl
Biological Process regulation of cell cycleIEA:Ensembl

Nucleus

Extensively phosphorylated on serine residues in the RS domain.